abstract：:Cancer cell heterogeneity is a universal feature of human tumors and represents a significant barrier to the efficacy and duration of anticancer therapies, especially targeted therapeutics. Among the heterogeneous cancer cell populations is a subpopulation of relatively quiescent cancer cells, which are in the G0/G1 c...

journal_title：Advances in experimental medicine and biology

authors： Davis JE Jr,Kirk J,Ji Y,Tang DG

更新日期：2019-01-01 00:00:00

abstract：:Gankyrin (also called PSMD10, p28, or p28GANK) is a crucial oncoprotein that is upregulated in various cancers and assumed to play pivotal roles in the initiation and progression of tumors. Although the in vitro function of gankyrin is relatively well characterized, its role in vivo remains to be elucidated. We have i...

journal_title：Advances in experimental medicine and biology

authors： Fujita J,Sakurai T

更新日期：2019-01-01 00:00:00

abstract：:This study investigated the effects of protein malnutrition and progesterone supplementation on the activities of a spectrum of lysosomal enzymes in tissue fragments of mouse liver and kidney. The working hypothesis was that the known anti-stress action of progesterone could have to do with the inhibition of lysosomes...

journal_title：Advances in experimental medicine and biology

authors： Stanisławska I,Witek B,Czarny-Działak M,Pałka-Łebek E,Łyp M

更新日期：2019-01-01 00:00:00

abstract：:Asian (Elephas maximus) and African (Loxodonta africana) elephants serve as important keystone, umbrella and flagship species. Despite that, population numbers are declining, due mainly to poaching and habitat destruction. Understanding reproductive mechanisms is vital to effective management, particularly insurance p...

journal_title：Advances in experimental medicine and biology

authors： Brown JL

更新日期：2019-01-01 00:00:00

abstract：:Research on the hierarchical nature of cell differentiation and heterogeneity in tissues has been performed by isolating and identifying cells by the use of monoclonal antibodies, cell sorting, microdissection, and functional assays. However, it is difficult to analyze continuous changes in cell differentiation and th...

journal_title：Advances in experimental medicine and biology

authors： Hashimoto S

更新日期：2019-01-01 00:00:00

abstract：:The accumulation of tau filaments in neurons is a pathological hallmark of various neurodegenerative diseases, including Alzheimer's disease. However, it is not the filamentous aggregates themselves, but non-filamentous tau species, tau oligomer, that is thought to be the culprit in tau-mediated neurodegeneration. The...

journal_title：Advances in experimental medicine and biology

authors： Maeda S,Takashima A

更新日期：2019-01-01 00:00:00

abstract：:The extraordinary mechanical properties of spider silk fibers result from the interplay of composition, structure and self-assembly of spider silk proteins (spidroins). Genetic approaches enabled the biotechnological production of recombinant spidroins which have been employed to unravel the self-assembly and spinning...

journal_title：Advances in experimental medicine and biology

authors： Humenik M,Pawar K,Scheibel T

更新日期：2019-01-01 00:00:00

abstract：:Myotonic dystrophies (DM) are rare inherited neuromuscular disorders linked to microsatellite unstable expansions in non-coding regions of ubiquitously expressed genes. The DMPK and ZNF9/CNBP genes which mutations are responsible for DM1 and DM2 respectively. DM are multisystemic disorders with brain affection and cog...

journal_title：Advances in experimental medicine and biology

authors： Fernandez-Gomez F,Tran H,Dhaenens CM,Caillet-Boudin ML,Schraen-Maschke S,Blum D,Sablonnière B,Buée-Scherrer V,Buee L,Sergeant N

更新日期：2019-01-01 00:00:00

abstract：:The microbiome comprises all the genetic material within a microbiota, that represents tenfold higher than that of our cells. The microbiota it includes a wide variety of microorganisms such as bacteria, viruses, protozoans, fungi, and archaea, and this ecosystem is personalized in any body space of every individual. ...

journal_title：Advances in experimental medicine and biology

authors： Astudillo-de la Vega H,Alonso-Luna O,Ali-Pérez J,López-Camarillo C,Ruiz-Garcia E

更新日期：2019-01-01 00:00:00

abstract：:Tau is a microtubule-associated protein that is involved in both normal and pathological processes in neurons. Since the discovery and characterization of tau over 40 years ago, our understanding of tau's normal functions and toxic roles in neurodegenerative tauopathies has continued to expand. Fast axonal transport i...

journal_title：Advances in experimental medicine and biology

authors： Combs B,Mueller RL,Morfini G,Brady ST,Kanaan NM

更新日期：2019-01-01 00:00:00

abstract：:The phospho-sphingolipid, ceramide 1-phosphate (C1P), has long been implicated as a dynamic bioactive agent. Over two decades of research has begun to characterize various regulatory roles for C1P from mammalian inflammatory response and wound healing to cellular proliferation and survival. As a metabolite of the intr...

journal_title：Advances in experimental medicine and biology

authors： Berwick ML,Dudley BA,Maus K,Chalfant CE

更新日期：2019-01-01 00:00:00

abstract：:Pertussis still represents a major cause of morbidity and mortality worldwide. Although vaccination is the most powerful tool in preventing pertussis and despite nearly 70 years of universal childhood vaccination, incidence of the disease has been rising in the last two decades in countries with high vaccination cover...

journal_title：Advances in experimental medicine and biology

authors： Ausiello CM,Mascart F,Corbière V,Fedele G

更新日期：2019-01-01 00:00:00

abstract：:Throughout evolution, eukaryotic cells have devised different mechanisms to cope with stressful environments. When eukaryotic cells are exposed to stress stimuli, they activate adaptive pathways that allow them to restore cellular homeostasis. Most types of stress stimuli have been reported to induce a decrease in ove...

journal_title：Advances in experimental medicine and biology

authors： Lacerda R,Menezes J,Candeias MM

更新日期：2019-01-01 00:00:00

abstract：:Since the birth of proteomics science in the 1990, the number of applications and of sample preparation methods has grown exponentially, making a huge contribution to the knowledge in life science disciplines. Continuous improvements in the sample treatment strategies unlock and reveal the fine details of disease mech...

journal_title：Advances in experimental medicine and biology

authors： Cole LM,Clench MR,Francese S

更新日期：2019-01-01 00:00:00

abstract：:The failure of complete remissions to reliably translate into cures in acute myeloid leukemia (AML) can be explained by the leukemia stem cell (LSC) paradigm, which hypothesizes that rare leukemia cells with stem cell features, including self-renewal capacity and drug resistance, are primarily responsible for both dis...

journal_title：Advances in experimental medicine and biology

authors： Karantanos T,Jones RJ

更新日期：2019-01-01 00:00:00

abstract：:Patient-derived human-induced pluripotent stem cells (iPSCs) have been critical in advancing our understanding of the underlying mechanisms of numerous retinal disorders. Many of these retinal disorders have no effective treatment and result in severe visual impairment and even blindness. Among the retinal degenerativ...

journal_title：Advances in experimental medicine and biology

authors： Cho C,Duong TT,Mills JA

更新日期：2019-01-01 00:00:00

abstract：:Peripherin 2 (also known as RDS/Prph2) is localized to the rims of rod and cone outer segment (OS) discs. The C-terminus of Prph2 is a critical functional domain, but its exact role is still unknown. In this mini review, we describe work on the Prph2 C-terminus, highlighting its role as a regulator of protein traffick...

journal_title：Advances in experimental medicine and biology

authors： Conley SM,Al-Ubaidi MR,Naash MI

更新日期：2019-01-01 00:00:00

abstract：:Extracellular vesicles (EVs) are membranous structures released by cells, including those of the retinal pigment epithelium (RPE) and photoreceptors. The cargo of EVs includes genetic material and proteins, making these vesicles essential in cell communication. Among the genetic materials, we find a large number of mi...

journal_title：Advances in experimental medicine and biology

authors： Sahaboglu A,Vidal-Gil L,Sancho-Pelluz J

更新日期：2019-01-01 00:00:00

abstract：:This study was designed to assess risk for retinal toxicity associated with administration of high-dose sildenafil citrate to dogs heterozygous for a functionally null mutation in Pde6a over a 4-month period. Three Pde6a +/- dogs were administered 14.3 mg/kg sildenafil per os and two Pde6a +/- dogs placebo once daily ...

journal_title：Advances in experimental medicine and biology

authors： Pierce KE,Curran PG,Zelinka CP,Fischer AJ,Petersen-Jones SM,Bartoe JT

更新日期：2019-01-01 00:00:00

abstract：:Autosomal dominant retinitis pigmentosa (adRP) is mainly caused by mutations responsible for rhodopsin (RHO) misfolding. Although it was previously proved that unfolded RHO is retained into the endoplasmatic reticulum (ER) eliciting ER-stress, consequent mechanisms underlying photoreceptor degeneration need to be furt...

journal_title：Advances in experimental medicine and biology

authors： Comitato A,Schiroli D,La Marca C,Marigo V

更新日期：2019-01-01 00:00:00

abstract：:Taurine is essential for the development and function of the central nervous system, retina, and cardiovascular system. It is a naturally occurring amino acid, abundantly found in the retina. It has been shown to exhibit antioxidant, neuroprotective, and osmoregulatory functions in the retina. We used conditionally im...

journal_title：Advances in experimental medicine and biology

authors： Gyawali A,Kang YS

更新日期：2019-01-01 00:00:00

abstract：:Mutations in the gene Crumbs homolog 1 (CRB1) are responsible for several retinopathies that are diverse in severity and phenotype. Thus, there is considerable incentive to determine how disruption of this gene causes disease. Progress on this front will aid in developing molecular diagnostics that can predict disease...

journal_title：Advances in experimental medicine and biology

authors： Ray TA,Cochran KJ,Kay JN

更新日期：2019-01-01 00:00:00

abstract：:Lead (Pb2+) is a developmental neurotoxicant that causes lifelong cognitive dysfunctions. In particular, Pb2+-induced frontoexecutive dysfunctions emerge later in life when the cortex is fully myelinated, thereby permitting the ability to assess the extent to which Pb2+ has developmentally impacted higher order cognit...

journal_title：Advances in experimental medicine and biology

authors： Neuwirth LS,Kim Y,Barrerra ED,Jo C,Chrisphonte JM,Hameed N,Rubi S,Dacius TF Jr,Skeen JC,Bonitto JR,Khairi E,Iqbal A,Ahmed I,Masood S,Tranquilee B,Thiruverkadu V

更新日期：2019-01-01 00:00:00

abstract：:CEP290 mutations cause a spectrum of ciliopathies, including Leber congenital amaurosis. Milder retinal diseases have been ascribed to exclusion of CEP290 mutant exons through basal exon skipping (BES) and/or nonsense-associated altered splicing (NAS). Here, we report two siblings with some preserved vision despite bi...

journal_title：Advances in experimental medicine and biology

authors： Barny I,Perrault I,Rio M,Dollfus H,Defoort-Dhellemmes S,Kaplan J,Rozet JM,Gerard X

更新日期：2019-01-01 00:00:00

abstract：:In this study, we investigated the hepatoprotective activity of the water extract derived from Octopus vulgaris meat (OM). First of all, a water extract prepared from OM (OMW) showed the high extraction yield (48.22%) and the highest taurine content (39.84%) in free amino acids. OMW exhibited the high value of reducin...

journal_title：Advances in experimental medicine and biology

authors： Lee W,Han EJ,Park E,Shin EJ,Han HJ,Jung K,Heo SJ,Kim EA,Kim KN,Kwak IS,Kim MJ,Ahn G

更新日期：2019-01-01 00:00:00

abstract：:Intravitreal (IVT) injection of ophthalmic therapeutics is the most widely used drug delivery route to the posterior segment of the eye. We employed this method to deliver our inorganic, catalytic antioxidant, cerium oxide nanoparticles (CeNPs), to rodent models of retinal degeneration. A single IVT of CeNPs delays di...

journal_title：Advances in experimental medicine and biology

authors： Wong LL,Barkam S,Seal S,McGinnis JF

更新日期：2019-01-01 00:00:00

abstract：:Taurine transporter (TauT) has been identified as a target gene of p53 tumor suppressor. TauT is also found to be overexpressed in variety type of human cancers, such as leukemia. This study showed that expression of TauT was upregulated by c-Myc and c-Jun oncogenes. To explore whether blocking of TauT inhibits tumor ...

journal_title：Advances in experimental medicine and biology

authors： Han X

更新日期：2019-01-01 00:00:00

abstract：:The eye is an excellent target organ for gene therapy. It is physically isolated, easily accessible, immune-privileged, and postmitotic. Furthermore, potential gene therapies introduced into the eye can be evaluated by noninvasive methods such as fundoscopy, electroretinography, and optical coherence tomography. In th...

journal_title：Advances in experimental medicine and biology

authors： Datta S,Peng H,Hulleman JD

更新日期：2019-01-01 00:00:00

abstract：:Taurine is traditionally used to treat Down Syndrome (DS); however, the actual foundation for this treatment is not well understood. DS patients suffer from disturbance of the proteostasis network (PN) due to aberrant calcium signaling, which eventually causes endoplasmic reticulum stress (ERS). Taurine has been sugge...

journal_title：Advances in experimental medicine and biology

authors： Chang H,Lee DH

更新日期：2019-01-01 00:00:00

abstract：:Genetic variants of high-temperature requirement A serine peptidase 1 (HTRA1) and age-related maculopathy susceptibility 2 (ARMS2) are associated with age-related macular degeneration (AMD). One HTRA1 single nucleotide polymorphism (SNP) is situated in the promotor region (rs11200638) resulting in increased expression...

journal_title：Advances in experimental medicine and biology

authors： Akhtar-Schaefer I,Reuten R,Koch M,Pietsch M,Langmann T

更新日期：2019-01-01 00:00:00

abstract：:So far, more than 20 species of Ganoderma (Lingzhi) fungi have been studied, including G. lucidum, G. sinense, G. japonicum, G. capense, G. australe, G. tsugae, G. applanatum, G. tropicus, G. boniense, G. duropora, G. resinaceum, G. theaecolum, G. cochlear, G. atrum, G. formosanum, G. boninense, G. colossum, G. concin...

journal_title：Advances in experimental medicine and biology

authors： Gong T,Yan R,Kang J,Chen R

更新日期：2019-01-01 00:00:00

abstract：:This study surveyed that the relationship between the frequencies of intake of taurine-contained nutritional drinks (TCND), and lifestyle and the purposes of intake it. The study was conducted a cross-sectional survey using 265 people (203 male, 62 female) aged 18-64 worked in two companies in Mie Prefecture, Japan be...

journal_title：Advances in experimental medicine and biology

authors： Ohtsuki M,Nishimura A,Kato T,Wakasugi Y,Nagao-Nishiwaki R,Shibata T,Okada H,Ohkubo T,Ma N

更新日期：2019-01-01 00:00:00

abstract：:Long-term studies of anti-pathogen and anti-tumor immunity have provided complementary genetic and pharmacological evidence for the immunosuppressive and immunomodulatory effects of Hypoxia-HIF-1α and adenosine-mediated suppression via the A2A adenosine receptor signaling pathway (Hypoxia-A2A-adenosinergic). This path...

journal_title：Advances in experimental medicine and biology

authors： Hatfield S,Veszeleiova K,Steingold J,Sethuraman J,Sitkovsky M

更新日期：2019-01-01 00:00:00

abstract：:Oral drug administration is the most favorable route of drug administration in the clinic. Intestinal transporters have been shown to play a significant role in the rate and extent of drug absorption of some, but not all, drug molecules. Due to the heterogeneous expression of multiple transporters along the intestine,...

journal_title：Advances in experimental medicine and biology

authors： Xue Y,Ma C,Hanna I,Pan G

更新日期：2019-01-01 00:00:00

abstract：:It has been reported that taurine intake in the past may have a positive effect on present cognitive function in the elderly. The purpose of this cross-sectional study was to investigate the need to develop an elderly-friendly home meal replacement (EF-HMR) containing taurine for the prevention of dementia in Korean a...

journal_title：Advances in experimental medicine and biology

authors： Park SH,Bae MA,Han SH,Seo YD,Kim SH,Chang KJ

更新日期：2019-01-01 00:00:00

abstract：:We previously showed that taurine administration contributed to the extension of time to exhaustion through exercise-induced hypoglycemia restraint, and we suggested that the activation of hepatic gluconeogenesis was initiated before the exercise with the taurine administration. We hypothesize that the extension effec...

journal_title：Advances in experimental medicine and biology

authors： Ohmori H,Matsumura M,Komine S,Kobayashi H,Kobayashi Y,Shiromoto J,Miyakawa S

更新日期：2019-01-01 00:00:00

abstract：:Plant chitinase hydrolyzing β-1,4-glycosidic linkages of chitin are major enzymes acting in plant-microbe interactions and are involved in self-defense against fungal pathogens. Chitosanases from soil bacteria are also involved in plant defense by hydrolyzing chitosan components of the fungal cell wall. The crystal st...

journal_title：Advances in experimental medicine and biology

authors： Fukamizo T,Shinya S

更新日期：2019-01-01 00:00:00

abstract：:Chitin is a linear polysaccharide of the amino sugar N-acetyl glucosamine. It is present in the extracellular matrix of a variety of invertebrates including sponges, molluscs, nematodes and arthropods and fungi. Generally, it is an important component of protective or supportive extracellular matrices that cover the t...

journal_title：Advances in experimental medicine and biology

authors： Moussian B

更新日期：2019-01-01 00:00:00

abstract：:Excessive oxidation and antioxidant imbalance resulting from several conditions may cause sperm DNA damage, which, in turn, affect male fertility, both natural and assisted. Sperm DNA damage transferred to the embryo might also affect the health of offspring. Several conditions associated with excessive oxidative stre...

journal_title：Advances in experimental medicine and biology

authors： Esteves SC

更新日期：2019-01-01 00:00:00

abstract：:Biomembranes separate a live cell from its environment and keep it in an off-equilibrium, steady state. They contain both phospholipids and nonphospholipids, depending on whether there are phosphate groups in the headgroup regions. Cholesterol (CHOL) is one type of nonphospholipids, and one of the most abundant lipid ...

journal_title：Advances in experimental medicine and biology

authors： Jiang QX

更新日期：2019-01-01 00:00:00